Endocrine Abstracts

Introduction: In type 2 diabetes the choice of the second drug after metformina is marked by the basic characteristics of the patient.Objetive: To analyze in real clinical practice the effectiveness of different antidiabetics.Material and methods: Observational study including patients with type 2 diabetes, in which we added to metformina different antidiabetics. We revised them 3-6 months from change.Results...

Objective: Cardiovascular risk factors (CVRF) persist with notable prevalence in patients with Cushing’s disease (CD) after remission: obesity/overweight up to 40%, hypertension (HTA) up to 60%, type 2 diabetes (DM-2) up to 60% and dyslipidemia up to 30% of cases. Persistence of metabolic syndrome in patients with controlled CD seems to be related to the duration of the disease before remission. The aim of this study is to describe the prevalence of CVRF in patients with ...

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

Introduction: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Studies have shown that patients using FGM test their glucose levels more often than those who use traditional blood glucose testing. Given that a higher rate of glucose testing has showed to improve glycemic control our objective was to describe the change in the glycemic control and time in euglycemic range in patients with FGM and the effect of the number of scans in this control....

Introduction: Non-functioning pituitary adenomas (NFPAs) represent the most common pituitary tumour. They usually appear in the middle age of life, without differences between genders. Mass growth produces the first symptoms so the diagnosis is usually late. Surgery is the first-line treatment with variable success (19-83%). The objective of this study is to evaluate the symptoms, diagnosis, treatment and final state of patients with NFPAs.Methods: Obser...

Introduction: The duration of hypercortisolism in Cushing’s disease (CD) appears to be inversely related to the reversibility of complications, which in turn increase mortality. This makes it necessary to identify medical therapies capable of normalizing cortisol overproduction before transsphenoidal surgery. The aim of this study was to determine if the clinical data of patients with CD before surgery allow predicting the presence and/or abundance of somatostatin (ssts) ...

Cinacalcet decreases and normalizes serum calcium levels across a broad severity range of primary hyperparathyroidism (PHPT), slightly reduces parathyroid hormone levels which generally remains elevated, whereas it has no effect on bone mineral density (BMD). Therefore, when administering cinacalcet to a patient with PHPT, concomitant treatment with an anti-catabolic drug should be considered.An open-labeled, prospective trial was conducted in 32 patient...

Acromegaly is caused by excessive GH secretion from pituitary adenomas. Transphenoidal surgery is the first-choice treatment, but new drug therapies (e.g. somatostatin analogues, SSA) offer promising avenues for medical treatment. Complementary diagnostic tools may assist this strategy, helping to refine drug choice. Here, we investigate the associations between radiological features and molecular phenotype of pituitary tumours from acromegalic patients. This observational stu...

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

Introduction: Overt hypothyroidism is associated with diastolic hypertension, but in subclinical hypothyroidism, data are inconclusive. HS tiroxina is a double-blind trial evaluating the effect of levothyroxine on blood pressure in patients with mild SH (TSH 5.0–9.9 mU/l and normal free T4) and moderate-to-high cardiovascular risk.Methods: We analized baseline data of the first 46 patients screened. Confirmatory thyroid function tests wer...